You could easily run two amps or more. There may be exceptions - amps that are super CPU hungry - but with most amps, 3 or 4 wouldn't break a sweat. Amp
captures can be piled on, as many as 8 or so in one lane. In "realistically necessary" terms, 2 amps and a half dozen pedals on one path with a little parallelism? Totally doable.
I basically use mine as a "Dual Cortex" as well, in the sense that the top path handles all of my guitar processing (and my guitar synth routing as well.) The bottom path usually gets called on for vocal processing, a bass guitar path, or whatever else is needed.
The global EQ thing was really overblown on forums. I think there may have been a bug as to when the low CPU warning was displayed. It's not exactly "efficient", but it's not the show-stopper it was made out to be.
There is a gap on preset switching; I assume it will vary depending on what's being loaded in the target preset. I certainly wouldn't be changing presets with a chord ringing out
but it's fine if it's used in tandem with Scene changes. If a sinigle preset can't get you all the way through a song, your band might be too progressive.