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Rock Star
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Really great to hear! What do your patches look like - effects pre and post? And do you use multiple amp channels on the Mesa or just one?
My patches are pretty simple and I built them using the 4cm template that Fractal tosses out as an afterthought on the absolute last preset…

Wah > phase or uni-vibe > drives in front of the amp, and delays with or without clean boost (along with noise gate from Fractal i/o) in amp's loop. I use the Mesa's actual reverb on cleans.
I did have to lower Output 1 by 6 dB (which I'm also doing when using Output 2 now for the Fuzz Head, in addition to turning off the noise gate).