Hey Ross !
Hope all is well. Just a suggestion for Genome.
A Multi-Band Compressor would be ideal ... brilliant for tightening up flubby lows and for smoothing out "crispy highs .... whilst leaving the core guitar mid-range signal in-tact / unaffected.
F.w.i.w its a staple in all the big players ... Axe, Stadium / Helix, L6, QC .. and even the "el-cheapo" Nux, Hotone, Soniccake etc.... stuff
I could be wrong but I cant see a way of doing this in the current 1.14 Genome Suite (?)
All the best, and thanks for all your ongoing support !
Ben