I almost never used the drive pedals on Helix or Fractal, because you could do the same things with amps, and you don't have to deal with compromises of the amp. Twin Reverb not giving you the drive sound you want? Swap it for e.g the Mesa Lonestar, or something completely different.
With real world rigs it's different because you need to work around any quirks and limitations your amp might have. You can't guarantee you can play a Deluxe Reverb cranked to edge of breakup all the time, so the sensible thing is to push it with pedals instead. Or if you are a high gain player, maybe your Recto needs a boost in front to tighten it up.
There's of course plenty of amps that are more than capable enough on their own, so you could slap a delay and reverb in the fx loop and be done with it.