@TubeNoob
Before you go down the rabbit hole buying stuff, take a breath and step back. A lot of people will swoop in and give you advice like spending more money all across different parts of your signal chain, but first there's a few things that might be important about you that would be helpful for us to know, so we can help you better.
1. How long have you been playing guitar?
2. How long have you been into tones with a lot of distortion?
3. What VH songs, or even just riffs, do you consider yourself good at? Entire albums worth or a handful of licks here and there. Either answer is completely fine. Even if you don't know any VH at all, that's totally fine too. The more info we know, the better we can help.
4. Can you post a cell phone audio clip or something of you playing your current setup so we can better identify what needs to be improved? You don't need to aim the camera at yourself, you don't even need to include the video part, really. Just take an audio recording with the phone mic aimed at the speaker. If you don't want to do that, that's fine, but if a picture is worth a thousand words, a video is worth 10,000, etc.
As far as pickups go, if you're a relatively new player, a Duncan JB is going to be more than fine to get you good high gain rock tones that are close enough to VH-like. And even if you change pickups, it might not have the impact you want if the rest of the rig isn't doing what you want it to do. It might just be a case of helping you dial in your amp. But if you've been playing for decades and are a die hard VH fan who needs to get his specific rig EXACTLY right, then that will call for a different strategy for helping.
These people recommending multi-thousand dollar amps and all kinds of stuff you haven't even thought of yet, without knowing the first thing about what kind of player you are or your understanding of gear, are clowns. Don't listen to them.