I play live and I'm in a band. I use my Helix for effects only in 4-cable-method with my amps, usually a Marshall JVM410HJS, Diezel VH4, or a Diezel D-Moll. I have other amps but I don't use them live. I've been doing this since 2016. Wow. That's quite a long time for a rig of mine to be dialed in and more or less static!
I also have an Axe FX III, which I have thought quite a lot about using live, because the FC12 controller would allow more possibilities. But honestly? Eric and Frank and the Line6'rs have been so cool to me that it would kinda feel like cheating!!!
I also record stuff with modellers. On the last album there are bits of Helix amp models, bits of the Kemper, loads of Helix effects as well as Boss and Strymon. I still used real amps for the majority of tones though.
In short - I can't really answer your poll, but I picked play live in a band and I play live but use my amp!