Both in conjunction seems like a very powerful setup!Yes POD Express is more user friendly for fx selection - but Catalyst is easier to tweak your amp sounds. For headphone or hooking to monitors etc I think POD Express wins. Even though the Cat FX are fiddly, it does have an editor so you can dial in each effect preset exactly how you want it vs the stock ranges of the POD Express FX. I'll be using both a ton both separate and together :)