I like stacking low gain pedals (as is evident on the latest iteration of my board) whether I'm going into a tube amp (e.g. my Shiva 20th) or digital (Tonex One/Tonex software, Axe-FX II, or plugins). When I want high gain, I need something else than my pedals, though they might provide the desired boost and/or alteration to an otherwise cool, high gain sound.
Edit: And no, I've never really thought this like changing IRs - as powerful as changing IRs are.
Edit: And no, I've never really thought this like changing IRs - as powerful as changing IRs are.