I've mostly owned amps that were versatile in their tones, with at least 2 channels, and when I gigged I set up multiple presets in my rig, my desire being to get close to the sounds of the guitar in the songs we covered.
If I still used real amps much, I'd own a Mesa JP2C, or MkV or VII, and my only fear would be if it ever needed any repairs, due to the complexity. But not being able to get great tones out of them, surely would not be a concern.
Ironically, now that I pretty much only use my Axe Fx III, I don't play much beyond high gain, even though I have every tone under the sun available.