I think at this point having an axe fix III, a quad cortex, the Boss IR thing, and the Friedman IR-whatever is a LOT of unnecessary overlap. And you don’t like the Orange. Not sure what else you have at this point. But you could definitely justify a purge.
And I am in agreement with Mongolio that the amps you’ve had have all been in the “yeah, of course that didn’t work out well for you” zone. And a 1x12 v-30 at low volume would probably make me want to give up electric guitar period.
That said…
I think trying to do Fender clean, plexi crunch and modern gain from one amp/cab would be setting yourself up for failure…
…I think even if you pulled that off, you’d still want Vox sounds…
…midi switching for an amp that is never going to be moved or used for live performance is simply a weird want feature…
Move some stuff. Take your time playing lots of stuff, preferably at not guitar center shops. Especially shops that could do a trade on your Orange cab for a cab you like. Find an amp you love the sound of, not one that does the most things. Pay cash, preferably not much more than what you get from moving stuff.
If you can do all of that, you might find an amp that really trips your trigger. Or you might find that it’s not worth the headache and the purge money can go towards the never ending pit of money that homeownership always seems to be…
But given your amp track record, it seems like really spending some long, quality time playing stuff before pulling the trigger is warranted.