I have gradually adjusted my grip over the past few years, so the pick is at ~45 angle to the strings, while also being as perpendicular to the strings as comfort will allow, so that slanting either backwards or forward (which I have to do both of, in many licks, sometime one right after another) will involve the least amount of "leaning the pick" as possible.
In going back and analyzing my technique, I have watched several of Bernth's videos, and zeroed in on some of the smallest details involved in this stuff. But it does make a positive difference.