im pretty sure it does. i have a pile of speakers ive run with mine- evm12l, emi dp12a, fane f70, celestion c90 & g12h30, and altec 417. in open and closed back 112, a thiele, and a 412. they ALL sound different- for sure. i think, probably the weirdest aspect though is configuration though cause theres a lot of places to get to similar places thatre just different enough from each other that one thing can poke out and ve annoying or amazing. and at different volume levels, its even more accentuated. but i think use case like that is kinda always the disruptor in talkin about any sound gear.