A different take regarding the 5050:
FWIW, I have the Synergy power amp, KSR PA50, the Syn30 head, PS2, as well as a switching system that allows me to power the Syn2 with any of my heads (for even more variety). i.e. by flipping a switch a can send the Syn2 to any power amp I own then to any cab I have.
Using the Syn5050 (bridged mode, 100W Mono, typically).... Keeps up with anything else pretty easily. Like anything else different modules like different power amps. I can't help but wonder if some folks complaining are trying to run it at 50W or have it misconfigured (not that it is super complicated).
I actually think the 5050 is well voiced for most of the modules... It wants the presence and depth wound up slightly more than my KSR f.ex. for most my modules but those controls have enough range to hit the sweet spot and when I swap between the KSR vs the 5050 back end the differences are pretty marginal for most things I am shooting for... and what with their convenient location on the front panel it is easy enough to torque it up or down as needed. It is virtually the same amp as the LXII in terms of how the amp behaves but the voicing differs (darker).
Would be totally comfortable with only that power amp and the Syn2 on a down size. That might actually be my personal fave of all my amp combos, TBH.
I know Jerry also has a similar setup (and even more gear), IIRC, and his take above is 180 degrees different.
Just goes to show you. There's so many variables, cabs, etc. Anyway the great thing about the modular thing is you can build your rig anyway you want. If you want a different power amp; have at it.