No but I've experienced discomfort and pain due to issues with my shoulders & hips, especially when playing standing up or sitting for extended periods of time. I tore my rotator cuff right before we did the YJM Australian tour, which I followed up by going straight into a 9 week circus season playing 7 shows a week so that required some serious managament and rehabilitation.
Certain neck shapes and the way certain guitars hang on a strap have made playing for long periods live uncomfortable at times too. I've probably done more damage to my hands by holding cooking utensils at weird angles than I have from actually playing though!