You need to make sure the resonant frequencies in the neck and body are not dissonant. Preferably a least an octave apart and a sympathetic internal. Tyler manages this. On cheap guitars this is pure chance.I just played a suhr the other day with obvious dead spots. My 200 euro jet guitars? Nothing like that, neither of them. I've come to think some of this is highly unpredictable, even if about wood.
How would you "get it right"?
If you are dealing with known qualities say a maple bolt on neck and an alder body it’s realistic to know what the ballpark results will be for a particular blank. Maple used in necks is easy because the weight hardly varies. You will get to know that X weight body blank will work with Y weight neck.