Precisely all those things are the ones I don´t want to deal with live.Well, there's been the Muse Receptor already.
Nah, that's really not an issue. Dial in your analog input level properly, then slap a gain plugin in front of any amp sim you may use. Adjust so it sounds good, save as a channel preset (that's a functionality that simply has to exist in a live host) and call it a day. You will never ever have to deal with it again.
And fwiw, I have been doing all that already, I programmed a rather elaborated live guitar setup for MainStage to see how well things would be working. There's been plenty of different amp modelers and input levels have been no issue at all as the first thing in each channel was a gain plugin, so that I could keep the interface's input level the same. As said, you only do all this once, save it as a template and/or channel strip preset and that was it.
Why?
Fwiw, I proably would *never* switch any complexed things inside HXN. I would just call up as many instances as I feel would be needed and switch between them. It's all a matter of the host (and of course of having enough CPU juice, but that should be absolutely no issue these days).
First of all, the Muse was an absolute fail. It lacked power, compatibility and whatnot... it was a lot of money for getting a very meh solution that was obsolete in no time.
Second, that thing of adding a gain plugin before the amp is a risk in certain live use cases. For instance, if you want to use NAM, and want to change the profile (for whatever reason), you are lost. You have to go to the gain plugin, adjust the gain (in the case you know what it is, or have the info at hand in that moment, which may be very optimistic), and do all of that quickly. Of course it can be done, of course it´s not rocket science... but it´s just tricky enough to not being a quick enough tweaking system for live use. Let alone that, if it´s a PC based syustem, you´d need to deal with a mouse, a keyboard, or a touch screen for the tweaks. For me, it´s just much more convenient having a floor unit, with dedicated knobs and no gain guessings, etc. You want to tweak, you just bend down and VERY EASILY do it without messing anything up. Of course, if your live use is very controlled, the presets are never tweaked, and there´s little chances of needing to build anything on the go... all the risks minimize, obviously. But even so... meh.
PC based HX Native vs a Helix LT, for instance? Well... the PC needs an audio interface, a USB cable, a PC (maybe a screen in case it´s not a laptop), power cables, USB noises risk, a midi controller, a cable for the midi controller, maybe a power supply for the controller (apart from the one for the PC)... Nah. For me, there´s no comparison. I massively prefer an LT on the floor than a complex rig full of cables, power adapters, several hardware gadgets, gain staging incertidumbre and much less user friendly on-the-fly tweaking.
And hey, I´m always thinking of building such a rig... There are some beautiful mini-pcs with included touch screens and powerful enough to run NAM and effects... I absolutely love the idea. But mate, when I put all the differences on the table, there´s no contest for live use compared to having only one unit on the floor. It´s just much safer, simpler, easier and trouble free.
Of course, this is just my preference.