I’ve only played around with this one using actual pedals.
I need a little break from the shreddy shreds tonight, maybe I’ll try cooking something up.
Up front I’d think you’d have to at least get into split coil mode on the EBMM, modeled fuzz needs all the help it can get!
He used a Fuzz Face back in the day, but by the 80’s he was doing the boosted Big Muff thing.
Sometimes it helps to put a compressor in front of a fuzz in the Fractal to help with sustain, it’s just tricky to get the fuzz elements sounding out that are the entire reason you’d use a fuzz with a compressed signal hitting it harder, it’s a happy balance of sustain/tone.