I've got a few different setups.
Fractal FM3 for all-in-one modeling. They just have the best combination of amp modeling, effects, quality, and power for my needs. I wish the UI was a bit easier and wish they had better code/release management but what can you do. I think next year I want to sell my FM3 and get an Axe FX 3 again, this time integrated into a studio desk. I use it 100% of the time sitting on a desk or table. Already have an FC-12.
Line 6 HX Stomp XL on a side board with a Strymon Iridium. I guess it's weird to use two different modelers at once but it does something different, which is to have amp modeling with physical knobs, and then flexible effects. I like but don't love the setup...I could see swapping out the XL for a standard sized Stomp to save space on the board, and I'm intrigued by the Walrus ACS-1 which is supposed to sound brighter and more open than the Strymon in a more compact pedal.
I don't like the Line 6 modeling as much all-in-one. There's something a little annoying about the amp tones that I can't put my finger on, like a little bit of a push in the upper mids/highs. But the effects are really nice all around. Workflow is great. I've had the big Helix a few times but sonically I just prefer the Fractal (even if it's not perfect there either).
I also use plugins from time to time, and enjoy the Neural DSP stuff for simplicity. I've got the Plini, Soldano, and Petrucci ones. I like the first two a lot and while I like the Petrucci effects don't like the core tones as much. I'll probably pick up the Tone King during the BF sale, maybe another one as well. Really wish I could mix and match within one console rather than multiple instances in a DAW but what can you do.
I've tried Kemper twice and didn't like the workflow or effects. I wish there was an updated version with a much better UI and integration with computer. Even then, I didn't love the profile concept. Can sound amazing but can also sound horrible. There's a little mid push there too but in a pleasing way where Line 6 is more grating.
Curious about Quad Cortex but not tempted yet. Price is way too high and I don't trust them yet.
Tried Headrush a few times and it's not bad but just a couple steps below the big dogs IMO.
Same for Boss, tried a couple GT-1000 pedals and they aren't bad but not at the same level as the others.
No interest in the really cheap modelers anymore.