It definitely isn't. Look at how the nanotube connects to the output transformer (hint there isnt one!). The design runs the tube at low voltage to extend its life beyond that of a traditional pre-amp tube which can already last decades (with some luck) and it's only there for tone/marketing. The actual output power is class D.
In theory the idea that the tube will typically outlast the amp and owner is solid. The concern would be that tubes usually have outliers and tube life can be impacted by factors like shock and vibration etc. If you are unlucky, it wouldn't be too hard to solder in a replacement, but you will be at their mercy on availability and price.
Oh wait, I just realized you are the idiot who thinks Line6 has not and will not update their modeling. In that case, ignore what I just said, the tube is the source of output power and should only last for about 200-500 hours of use.