A lot of people put their gain stages into the loops, and then have their delays and reverbs down stream, not in loops, and switch them by midi commands at the same time as bringing various gain stages in and out.
It's more of a "I want Helix snapshots but with my own pedals" type of setup, rather than explicitly making sure pedals aren't in the signal path when not required.
I have the big boy G3, which has 12 loops, and I can honestly say I've never used all of them, and I've never really utilised the unit to its full potential. I'll probably sell it tbh, coz I'm actually loving going back to tap dancing at the moment!