I have a couple of go-to crunch amps in HX that I will use depending on what guitar I'm playing and what I'm looking for out of the amp.
Brit Trem Brt: This gets used with a PAF-loaded Les Paul and various IRs for a general LP/Marshall crunch - greenbacks are classic here. Gain is anywhere from half to all the way up depending on your pickup output, bass is under halfway, mids/treble/presence get pushed up 6-7 or until the amp's response gets a little more glass and tightness. Rolling down the guitar volume should clean up pretty well. This also works really well with Teles.
Mesa Mark IV: Used with Teles and LPs, drive ~8, treble 6-8, mids 3, bass 0-3, classic V on the graphic with the mid-band brought back up to ALMOST the center line so the guitar doesn't disappear in the mix. There other variations of this that I use with more treble and less bass (more aggressive) or more bass and less treble (rounder, less gain) that can be very useful. I use either greenbacks or V30 IRs depending on how woody I want the midrange to be.
Deluxe Reverb (vib): This one is not intuitive, but it's one of my favs and kind of a hidden gem. Crank the drive up into the 6-10 range so the amp is overdriving. Drop the bass below 3, push the treble up around 6-7, and put it through a 4x12 or something with a closed back. In other words, almost treat it like a Mesa Mark amp in the EQ and gain structure. Its a very punchy, raw OD tone that takes pedals well and cleans up into a greasy clean tone with some hair and compression.