That's pretty much our take too, except replace "powered speakers/""FRFR"" solutions" with "your favorite playback system," which could very well be a tube power amp and cab.
Any combo with the full compliment of Helix amps and effects would require some way of controlling it live; as soon as you add a robust enough controller—even if it connects and is powered via FBV—the only convenience a Helix combo would give you is one fewer audio cable (Stomp > Amp) and one less power supply (Stomp). But you're then stuck with whatever cabinet and speaker we'd give you. The convenience argument holds water on a spreadsheet, but not really in practice.
The bigger issue is whether or not the market would embrace a $2000+ digital amp with no tubes. There's definitely a "I won't buy this amp because new amps should last until 2070 and the software might not be supported in 2030" thing going on. Which I kinda get, because my old Parker MIDI Fly couldn't be tweaked because I didn't have a Windows 98 System.
EDIT: I shoulda just said "because it'd have knobs."