My preference is to use a multiple amp WDW routing. My rack has proven to have issues, so I have to troubleshoot and rewire that. Rack has been out of commission for a while now...at least a year.
So, I had been playing through a Fender CyberTwin SE and running the speaker outs to a couple EV 12L Classic spread very wide. This producing much less (ground loop) noise. I did notice a bit of fizz at the attack of every note and guessed it was power noise. Well, no, it's CyberTwin junk power amp.
I found that out after not realizing (for 20 years) that CyberTwin line out can feed a power amp of user choice (doh!) I had just assumed it was for direct recording or direct to FOH. I tried my VHT amps and oh my, the glory!!! Fizz is gone and gorgeous tube amp power. Makes the CTs sound awesome.
I also tracked down ground loops from socket to socket in my office studio. We had a new board installed in 2019 and the electricians were unable to deliver the power requirements I asked for. Nevertheless, I have three sockets in a good place and in France power is 230v. If I get power from the right place, operation is very quiet for electrical noise.
I also use an APC BackUPS 1500 Pro which can be very helpful taming electrical noise. There is an electrical filter section that cleans out wireless interference as my main router and Devolo wifi DA is that same room.
In Europe and the UK, our power is definitely more clean than in USA, for example. In the UK I seldom had any electrical noise issues.
That said, yesterday, at my residence in France, my APC shut off the AC due to "electrical noise". It only went to DC for a short while, but nevertheless it cut power for a noise blast.