Quad Cortex is far better for "on-the-fly, tweak as you go" type programming. Literally "tap a thing, turn knobs/switches" which is about as close as I've seen a digital modeler get to the pedalboard experience. I like it a lot.
Yeah, QC doesn't have a computer editor but it also doesn't really need one. An editor software would be convenient mostly in a recording situation where you want to be looking at your computer monitor as you have a DAW and whatnot open.
Even if you use Axe-Edit on Fractal, you most likely are doing something like this: put your pick down (or hold it awkwardly), pick up the mouse, move virtual knobs around, grab your pick again, play and repeat. Unless you use the looper to play some riffs as you tweak.
It's alright, but nothing really beats dedicated hardware knobs. Which happens to be where the Fractal onboard UI tends to fail as the arrangement of its controls isn't particularly great and needs a lot of menu diving and paging around, switching between rows etc. You can learn to live with it, but it's a bit of a chore.
Axe-Edit does offer a lot of convenience features. The Quick build feature lets you add the blocks you need really fast and there is less thinking about how to manage the grid most effectively like you have to on Helix and QC. Channels make it intuitive to switch between models or settings. Parallel routing is straightforward.
Assigning footswitches is easy enough on the QC, but also pretty limited. Fractal on the other hand offers a ton of control but it's often way too complicated for what users mostly want footswitches to do. Helix is by far the best in this regard IMO.
The way I use my Axe-Fx 3 is pretty much the template setup
@DrewJD82 describes. Take the time to make one really well setup preset, with footswitching and everything configured then just make variations of that.
I like Fractal less for just experimenting with sounds and effects because the effort to do so requires more than on my pedalboard for example. The more you have preprogrammed and the less you touch the stuff, the better Fractal works for me.